Roso 20mg

Roso

COMPOSITION:

Each film coated tablet of Roso contains:

Rosuvastatin 5 mg   (As Rosuvastatin Calcium)

Rosuvastatin 10 mg (As Rosuvastatin Calcium)

Rosuvastatin 20 mg (As Rosuvastatin Calcium)

Rosuvastatin 40 mg (As Rosuvastatin Calcium)

DESCRIPTION:

Rosuvastatin is a selective and competitive inhibitor of HMG-CoA reductase, which converts 3-hydroxy-3-methylglutaryl coenzyme A to mevalonate, (a precursor for cholesterol). The primary site of action of rosuvastatin is the liver, the target organ for cholesterol lowering. Rosuvastatin increases the number of hepatic LDL receptors of the cell surface, enhancing uptake and catabolism of LDL and it inhibits the hepatic Synthesis of VLDL, thereby reduces elevated VLDL, LDL-cholesterol, total cholesterol and triglycerides and increases HDL-cholesterol.

INDICATION:

Roso is indicated for the following cases:

– Prevention of major cardiovascular events in patients who are estimated to have a high risk for a first cardiovascular event as an adjunct to correction of other risk factors.

– Treatment of homozygous familial hypercholesterolaemia as an adjunct to diet and other lipid lowering treatments.

-Treatment of primary hypercholesterolaemia (type Ila including heterozygous familial hypercholesterolaemia) or mixed dyslipidaemic (type IIb) as an addict to diet when response to diet or exercise and weight reduction is inadequate.

DOSAGE:

Before treatment initiation the patient should be placed on a standard cholesterol- lowering diet that should continue during treatment.

Roso may be given at any time of day, with or without food, and the dose should be individualized according to the goal of therapy and patient response.

Treatment of hypercholesterolaemia: The recommended start dose is 5 or 10 mg orally once daily, and a dose adjustment to the next dose level can be made after 4 weeks, if necessary. A final titration to the maximum dose of 40 mg should only be considered in patients with severe hypercholesterolaemia at high cardiovascular risk and with specialist supervision.

Prevention of cardiovascular events: The recommended dose is 20 mg daily.

In children 6 to 9 years of age with heterozygous familial hypercholesterolaemia, the usual dose range is 5-10 mg orally once daily, and in children 10 to 17 years of age the usual dose range is 5-20 mg orally once daily.

Children and adolescents should be placed on standard cholesterol-lowering diet before Rosuvastatin treatment initiation this diet should be continued during Rosuvastatin treatment. Roso tablet 40 mg is not suitable for use in Paediatric patients.

Roso is not recommended for use in children younger than 6 years.

In the elderly >70 years: A start dose of 5 mg is recommended.

Storage Conditions:

– Keep the medicine in a dry place at a temperature below 30 °C.

– Keep the medicine out of the reach of children.

– Protect the medicine from direct sunlight.

– Do not use Roso tablets after expire date.